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McKelvey School of Engineering

Brown School

IMSE Seminar: "Engineering nano-biomaterials for tissue fabrication and regenerative medicine"

Monday, November 13, 2023 | 1:00 PM - 1:50 PM

Stephen F. & Camilla T. Brauer Hall, 12
6548 Forest Park Pkwy, St. Louis, MO 63112, USA

Su Ryon Shin, Assistant Professor of Medicine, Brigham and Women's Hospital and Harvard Medical School. 

Recapitulating inherent heterogeneity and complex microarchitectures of native tissues for developing clinically relevant three-dimensional (3D) tissues or organs has emerged as a potential solution for tissue regeneration. Recently, advanced microfabrication technologies and functional biomaterials have been developed to create biomimetic tissue constructs and to mimic the functional behaviors of native tissues. However, several significant challenges in tissue engineering still exist, such as recapitulating the in vitro, 3D hierarchical microarchitecture comprised of multiple cell types and the extracellular matrix (ECM) components of native tissues and achieving the continuous function and viability of engineered tissues after implantation. To do this, we developed an advanced multi-material bioprinting platform that employs self-healing ECM-like supporting baths and a programmable microfluidic device, which can quickly switch between different materials, biological reagents, and cells. The self-healing ECM-like colloidal gels can physically support soft 3D printed constructs to maintain their complex geometries while enabling rapid cell infiltration and vascularization in vivo. This advanced bioprinting platform allowed us to fabricate complex geometrical structures such as centimeter scale pre-vascularized 3D skeletal muscle tissue constructs and skeletal muscle connective tissue (MCT)-layered myofibers through the development of stem cell fate-controlling biomaterials that achieve both myogenesis and fibroblast differentiation in a locally controlled manner at the single construct. Another challenge is the survival of bioprinted 3D tissue constructs at the injured area, which is fully dependent on the oxygenation derived by its connection to the blood circulation of the host body. Incorporating functional biomaterials (i.e., oxygenating micromaterials) into cell-laden 3D constructs could solve these problems, as it immediately allows for oxygen delivery. Therefore, we have developed oxygenating micromaterials containing molecules that release oxygen upon hydrolysis over a duration of two weeks, allowing the implant to survive its non-perfused phase and enabling the continued functioning of living implants. We recently observed promising results that showed mesenchymal stem cell (MSC)-laden oxygenating hydrogels to improve angiogenic factor secretion and vessel formation in vivo significantly. Self-oxygenation of tissues thus represents a novel, effective, and widely applicable strategy to enable the vascularization of living implants, which is expected to advance organ transplantation and regenerative medicine applications.      Hosted by: Alexandra Rutz, BME

Event Type

Seminar/Colloquia

Schools

Arts & Sciences, McKelvey School of Engineering

Topic

Science & Technology, Medicine & Health

Website

https://imse.wustl.edu/

Department
Institute of Materials Science & Engineering
Event Contact

Beth Gartin, bgartin@wustl.edu

Speaker Information

Su Ryon Shin, PhD, received a doctoral degree from Hanyang University, South Korea. In 2010, she joined the staff at the Brigham and Harvard Medical School (HMS) as a postdoctoral research fellow in the Division of Engineering in Medicine. Shin was promoted to instructor at HMS in 2014 and became affiliated with the Harvard-MIT Division of Health Sciences and Technology. Today, Shin is an Assistant professor of medicine at the Brigham and HMS. Her interdisciplinary approach has earned her a growing international reputation for her work in nanomaterials science, regenerative medicine, and biomedical engineering. Her research focuses on developing micro- and nano-technologies to control cellular behavior, with particular emphasis on developing micro-scale biomaterials and engineering systems for various biomedical applications. Also, Dr. Shin has been developing and testing of integrated organs-on-chip systems with built-in biosensors.  During her research period at the Brigham, Dr. Shin has been extremely prolific in her work, which has resulted in several funded grants by National Institutes of Health (NIH), American Heart Association (AHA), Air Force Office of Sponsored Research, Toyota Motor Corporation, and the Advanced Regenerative Manufacturing Institute of the U.S. Department of Defense, etc. In addition, she has published over 148 papers in peer-reviewed journals such as Nature Protocol, PNAS, Science Advanced, Advanced Materials, ACS Nano, Angewandte Chemie, etc. Her H index, which is a measure of scientific productivity, is already at 67. In just a few years she has been cited over 19,500 times. Her work has also attracted funding through the BWH Stepping Strong Innovator Awards and Innovation Evergreen Award. Faculty, students, and the general public are invited. 

 

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