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IMSE Seminar: "A Tale of Two Layers: Puzzles of the Airway Surface Layer"

This is a past event.

Monday, October 20, 2025 1 PM to 1:50 PM

6548 Forest Park Pkwy, St. Louis, MO 63112, USA

https://imse.washu.edu/index.html
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Dr. Michael Rubinstein, Professor, Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University

The classical view of the airway surface layer (ASL) of lungs is that it consists of two layers – the mucus and periciliary layer (PCL). Mucus is assumed to be a gel that is propelled by cilia and rides on the top of PCL, which is assumed to be a low viscosity dilute liquid. I propose a completely opposite model of ASL: PCL is not dilute liquid, but instead consists of a dense brush of mucins attached to cilia, while normal mucus is not a gel, but a dilute liquid with a viscoelastic skin. Both physical and biological implications of the new model and the remaining puzzles will be discussed.

Host: Dr. Chris Cooper, EECE

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