Precision medicine is an emerging field that stratifies patient groups based on molecular and cellular levels of data, followed by individualized treatment for better health outcome. One key enabling tool in precision medicine is a biomedical device that can acquire cellular/molecular information specific to targeted patient groups. To achieve this specificity, such devices should ideally be built in a scalable array form, whose number of functional pixels can be scaled up to collect high-content data. The resulting arrays can be used to probe cellular disease models or monitor the dynamics of multiple biomarkers simultaneously. If successful, such devices can ultimately be integrated to drug screening and bedside testing systems to advance drug therapies and point-of-care solutions. Motivated by these, our research has been focused on developing scalable, high precision optoelectronic lab-on-a-chips for cell interfacing and biosensing applications that may add to next-generation precision medicine. In this talk, I will introduce our recent work on: 1) high-resolution cell interfaces for single-cell optogenetics and on-chip Ca2 imaging; and 2) label-free biochip technologies for DNA detection and cytokine monitoring. I will close with a vision of our future research.
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