Tuesday, November 28 | 11:00 AM - 1:00 PM
Uncas A. Whitaker Hall, 100
6760 Forest Park Pkwy, St. Louis, MO 63105, USA
Development of Noninvasive High-resolution Electrophysiological Imaging System in Human Uterus and Other Electrically Excitable Organs
Abstract: Uterine peristalsis, characterized by spontaneous slow-wave contractions of the subendometrial layer of the uterine myometrium, occurs throughout the menstrual cycle. Disruptions in peristalsis patterns may occur in women experiencing abnormal uterine bleeding, endometriosis, and infertility. Current tools to measure uterine peristalsis in humans have limitations that hamper their research and clinical utility. Therefore, I developed an electrophysiological imaging system with wearable sensors to noninvasively image the four-dimensional electrical activation patterns with high spatial and temporal resolution and coverage.
In this presentation, I will introduce the technical development of uterine peristalsis imaging (UPI) to study complex UP patterns with multi-parametric electrophysiological signatures. Subsequently, I will illustrate the diverse and complex the UP patterns captured and classified by our imaging system. Furthermore, I will delve into the details of one prospective observational cohort study employing a randomized control approach to investigate how use of transvaginal ultrasound (TVUS) alters physiologic UP in gynecologic patients. This study is designed to uncover the nuanced changes brought about by TVUS usage. Additionally, I will discuss our recent clinical findings pertaining to UP and its associations with reproductive hormones, obesity, and endometrium development. These insights contribute significantly to our understanding of the physiological intricacies involved. Moreover, I will introduce a couple of ongoing human studies and how the imaging system has the potential to provide benefits to patients in clinical settings.
Next, I will elaborate on the adaptation of my developed technique for the longitudinal imaging of the electrical patterns in utero-placenta-pump (UPP) throughout pregnancy and study the correlation between the electrical patterns and the potential risk of fetal growth restriction (FGR).
Lastly, I will elaborate on the modifications made to our imaging system to extend its imaging capabilities towards other human electrically excitable organs like human cortex and skeletal muscles. This extension will allow us to investigate significant and intricate physiological and pathological conditions.
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