Structured Light Radial-View Endoscope Imaging Development for Evaluation of Human Tissue Optical Properties
Abstract: In this thesis, we improved a structured light methodology designed to accurately estimate tissue optical properties through a single snapshot. This new approach presents a significant enhancement over the traditional three-phase spatial frequency domain imaging system, by not only simplifying the operational procedure but also maintaining high accuracy in optical property measurement. Leveraging this enhanced algorithm, we have developed a low-cost, compact, and radial-view endoscope prototype. This prototype represents a leap forward in endoscopic technology, combining affordability with high functionality and user-friendly design. To assess the performance and reliability of our endoscope, we conducted comprehensive evaluations involving tissue-mimicking phantoms, as well as ex vivo imaging of human waist vessels and colorectal tissues. These experiments were demonstrated at reconstructing absorption and reduced scattering coefficients, thereby proving the prototype's capability in accurately capturing the optical characteristics of biological tissues. The results not only validate the effectiveness of the structured light approach in optical property assessment but also highlight the potential of our endoscopic prototype in enhancing diagnostic procedures for biological tissue imaging.