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McKelvey School of Engineering

EECE Seminar - Nicholas Graham

Friday, December 3 | 11:00 AM - 12:00 PM

Virtual Event

*Please note this seminar will be virtual, with no in-person component*

 

Nicholas A. Graham, Assistant Professor
Mork Family Department of Chemical Engineering and Materials Science
University of Southern California
 

Abstract: “Omics” technologies have enabled network-level measurements of genes, proteins, and metabolites from cellular models of disease. Systems biology attempts to synthesize these quantitative measurements into data-driven models to explain biological function. Here, I will discuss three different engineering systems biology approaches using metabolomics, proteomics, and bioinformatics to identify or discover drugs for cancer and aging. First, using metabolomics, we designed a synergistic drug combination that mimics nutrient deprivation to kill cancer cells. Second, by integrating a proteomic signature of cellular senescence with large-scale drug screening databases, we predicted and then validated that EGFR inhibitors are toxic to senescent human mammary epithelial cells, a model system for aging. Finally, we developed a bioinformatic approach to integrate gene expression data with drug screening data from hundreds of cancer cell lines to identify clinically approved drugs whose efficacy depends on metabolic pathway activity. Taken together, these studies demonstrate how metabolomics, proteomics, and bioinformatics can all serve to identify drugs for cancer and aging.

Event Type

Seminar/Colloquia

Schools

McKelvey School of Engineering

Topic

Science & Technology

Department
Energy, Environmental & Chemical Engineering
Event Contact

Jesi Hempstead

Speaker Information

Dr. Nicholas Graham is an Assistant Professor of Chemical Engineering at the University of Southern California. He received a BS in Chemical Engineering and French from Washington University in St. Louis, followed by an MS and a PhD in Chemical Engineering from Caltech with Anand Asthagiri. He then completed an NIH-supported postdoc in Molecular and Medical Pharmacology at UCLA with Thomas Graeber before joining USC. His lab uses systems biology approaches including proteomics, metabolomics, and bioinformatics to study diseases including cancer, aging, and diabetes.

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