Friday, December 3, 2021 | 11:00 AM - 12:00 PM
Stephen F. & Camilla T. Brauer Hall, Brauer 12
6548 Forest Park Pkwy, St. Louis, MO 63112, USA
Dr. Sheng Chih (Peter) Jin
Assistant Professor of Genetics and Pediatrics, Washington University School of Medicine
Congenital disorders, also known as birth defects, are conditions present from birth. The sporadic nature of most congenital disorders has limited the utility of traditional genetic approaches in the past. Advances in next-generation sequencing have discovered the genetic causes of a large proportion of patients with congenital disorders. Despite remarkable progress in the identification of genes and pathways involved in congenital disorders, the cause of most cases remains elusive. It is becoming evident in the field that simple genetic models do not entirely explain the causes of all congenital disorders and more nuanced approaches are required. This talk discusses the challenges in identifying genetic causes from genomic data. I will also present several of our recent work that aims to determine the complex genetic basis of congenital disorders using the large-scale integrative analysis of omics data.
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