The McKelvey School of Engineering at Washington University in St. Louis is launching a new center focused on the topic of biomolecular condensates. Intracellular phase transitions that couple of segregative (phase separation) and associative (percolation) phase transitions, have emerged as a new framework for understanding how macromolecules and biochemical reactions are organized in space and time within live cells. There is growing interest in this topic with the very exciting prospect that condensates can be engineered for bespoke functionalities while also paving the way to helping us understand how various degenerative and proliferative disorders arise.
Highlighted speakers:
Anthony Hyman, Max Planck Institute, Cell Biology and Genetics
Talk title: Condensates in Cell Physiology & Disease
Amy Gladfelter, University of North Carolina
Talk title: The RNA Code in Condensates
Tuomas Knowles, University of Cambridge
Talk title: Kinetics of Protein Phase Transitions
Matthew Tirrell, The University of Chicago
Talk title: Phase separation driven by polyelectrolyte complexation
Clifford Brangwynne, Princeton University
Talk title: Liquid Motors – Condensates as mechanical force generators
Helen McNeill, BJC Investigator, WashU School of Medicine
Talk title: Nemp1 in mechanobiology and chromatin organization
Lucia Strader, Duke University
Talk title: Condensation to attenuate transcription factor activity in plants
Michael Rosen, UT Southwestern Medical Center
Talk title: A phase separation model for chromatin organization
Tammy Haney: haneyt@wustl.edu
Cellular Observations and Molecular Grammar
Amy Gladfelter, University of North Carolina
Alex Holehouse, WashU School of Medicine
Yuna Ayala, Saint Louis University
Anthony Hyman, Max Planck Institute, Cell Biology and Genetics, Dresden
Physical Principles
Tuomas Knowles, University of Cambridge
Matthew Lew, WashU McKelvey School of Engineering
Matthew Tirrell, The University of Chicago
Meredith Jackrel, WashU, Department of Chemistry
Andrea Soranno, WashU School of Medicine
Mechanobiology
Clifford Brangwynne, Princeton University
Shankar Mukherjee, Washington University in St. Louis
Helen McNeill, BJC Investigator, WashU School of Medicine
Genome Organization and Transcription
Michael Rosen, UT Southwestern Medical Center
Michael Vahey, WashU McKelvey School of Engineering
Lucia Strader, Duke University
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