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McKelvey School of Engineering

CBAC Seminar: Mitochondrial ATP Production in Cardiac Cells

Tuesday, February 9 | 10:00 AM - 11:00 AM

Virtual Event

As part of the CBAC Seminar series, join us for this presentation by W. Jonathan Lederer, a Professor of Physiology & the Director of the Center For Biomedical Engineering & Technology, University of Maryland School of Medicine.

For more information, contact Huyen (Gwen) Nguyen at hbnguyen@wustl.edu

Event Type

Lectures & Presentations, Seminar/Colloquia


McKelvey School of Engineering


Science & Technology, Medicine & Health

Biomedical Engineering, Cardiac Bioelectricity & Arrhythmia Center
Event Contact

Huyen (Gwen) Nguyen | hbnguyen@wustl.edu

Speaker Information

W. Jonathan Lederer, MD-PhD
Director, Center for Biomedical Engineering and Technology
Professor of Physiology
University of Maryland School of Medicine

Biography: As a principal investigator for over 35 years, Lederer has led his team to several key discoveries in calcium signaling, including the 1992 discovery of calcium sparks, the calcium signals in the heart that underlie all heart contractions, as well as all other muscles and excitable cells. Lederer’s discovery and subsequent study of calcium sparks has led to the development of a new area of research in local signaling events.

Earlier in his career, while studying at Yale, Lederer discovered and characterized the transient inward current, a finding that contributed to medicine’s understanding of the arrhythmogenic delayed after-depolarization (DAD) and early after-depolarization (EAD) events. He also pioneered the use of confocal imaging in cardiac research, developing a number of techniques and tools. He is a leader in developing and implementing novel imaging technologies relevant to muscle biology that capture real-time signals at a high temporal and spatial resolution.

Recent discoveries include a new calcium-dependent, mechano-chemical signaling pathway called X-ROS, which links calcium signaling to the cytoskeleton and contraction. Lederer is Professor of Physiology in the School of Medicine and Director of the Center for Biomedical Engineering and Technology.

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