A guide to events on our campuses.

Assembly Series

A tradition of convening thought leaders since 1953

McKelvey School of Engineering

Brown School

BME Seminar: Stephanie Willerth, PhD

Thursday, February 24, 2022 | 10:00 AM - 11:00 AM

Uncas A. Whitaker Hall, 218
6760 Forest Park Pkwy, St. Louis, MO 63105, USA

Presenting on “3D bioprinting personalized neural tissue models”

Stephanie Willerth, PhD, Professor, Canada Research Chair in biomedical engineering, acting director of centre for biomedical research, and acting director of undergraduate biomedical engineering program at the University of Victoria, will speak at 10 a.m. on Thursday, February 24, 2022 in Whitaker 218. If you plan to attend virtually, registration is required.

Abstract:
3D bioprinting can create living human tissues on demand based on specifications contained in a digital file. Such highly customized, physiologically-relevant 3D human tissue models can screen potential drug candidates as an alternative to expensive pre-clinical animal testing. The Willerth lab has developed a novel fibrin-based bioink for bioprinting neural tissues derived from human induced pluripotent stem cells (hiPSCs), which can become any cell type found in the body. Our team uses Aspect Biosystems' novel RX1 bioprinter featuring Lab-On-a-Printer™ (LOP) technology as it enables us to fabricate complex structures found in healthy neural tissues. We were the first group to use this cutting edge bioprinter to generate tissues from pluripotent stem cells. The microfluidic LOP™ printhead cartridges generate cell-containing hydrogel fibers of defined diameters that are precisely deposited into defined 3D structures using a sheath fluid that triggers hydrogel cross-linking of the bioink. The sheath fluid also insulates cells within the fiber from shear stress, protecting fragile primary cells from shear-induced cell death. This process allows us to maintain high levels of viability (>90% post printing) not previously seen in the literature. Here I will discuss the latest work from our group detailing the composition of our 3D bioprinted tissues and our new spin-off company - Axolotl Biosciences.

NOTE:
Parking is available outside of Whitaker Hall in the East End Garage. Click here for the map. If taking the subway, the nearest metrolink stop is Skinker.

Event Type

Seminar/Colloquia

Schools

McKelvey School of Engineering

Topic

Science & Technology, Medicine & Health

Department
Biomedical Engineering
Hashtag

#WashUBME

Event Contact

Mimi Hilburg | mhilburg@wustl.edu

Speaker Information

Since starting as faculty in 2010, Dr. Willerth has successfully run an interdisciplinary research program investigating neural tissue engineering treatments for disorders of the central nervous system and training highly qualified personnel. Her research combines stem cells, tissue engineering, drug delivery, cellular reprogramming and 3D bioprinting. She has been recognized as a leader in the fields of Biomaterials and Tissue Engineering as evidenced by her Tier II Canada Research Chair in Biomedical Engineering, being named a Woman of Innovation in 2017, a Young Innovator in Cellular and Molecular Bioengineering in 2015, and served as the President of the Canadian Biomaterials Society in 2017-8. She also currently serves as the Acting Director of the Centre for Biomedical Research located at the University of Victoria. Her work in training HQP at the undergraduate level led her to be named the winner of the 2018 REACH award for Excellence in Undergraduate Research-inspired Teaching – a prestigious University-wide award.

Subscribe
Google Calendar iCal Outlook

Discussion