Sign Up

6760 Forest Park Pkwy, St. Louis, MO 63105, USA

#WashUBME

Presenting on "The mechanobiology of pulmonary hypertension progression due to left heart failure"

Naomi Chesler, PhD, professor of biomedical engineering at the University of California, Irvine, will speak at 10:00 a.m. CST on Thursday, April 7, 2022 in Whitaker 218.

Abstract:
Pulmonary hypertension (PH) due to left heart failure (PH-LHF) is the most common cause of  
PH and is associated with a high morbidity and mortality. LHF impacts nearly 5.9 million adults and contributes to 1 out of every 9 deaths in the United States. Due to a lack of well-characterized animal models and the limitations of human subjects research, investigations into disease pathophysiology and progression have been limited and much of current understanding of the mechanisms of this disease remains speculative. We hypothesize the biomechanical and mechanobiological mechanisms are key to disease progression, especially at the pulmonary capillaries. In particular, we hypothesize the increased cyclic stretch and decreased wall shear stress drive the transition from isolated post-capillary pulmonary hypertension (aka pulmonary venous hypertension) to combined pre-/post-capillary pulmonary hypertension. To investigate these mechanical mechanisms, we apply multiscale computational and experimental approaches including in vitro studies, ex vivo studies, and in vivo studies in both large and small animal models of disease. We use a similar suite of methods to investigate the determinants of right ventricular failure, which is the common final pathway of mortality due to PH.

Host: Dr. Lori Setton, Washington University in St. Louis

NOTE:
Parking is available outside of Whitaker Hall in the East End Garage. Click here for the map. If taking the subway, the nearest metrolink stop is Skinker.

6760 Forest Park Pkwy, St. Louis, MO 63105, USA

#WashUBME

Presenting on "The mechanobiology of pulmonary hypertension progression due to left heart failure"

Naomi Chesler, PhD, professor of biomedical engineering at the University of California, Irvine, will speak at 10:00 a.m. CST on Thursday, April 7, 2022 in Whitaker 218.

Abstract:
Pulmonary hypertension (PH) due to left heart failure (PH-LHF) is the most common cause of  
PH and is associated with a high morbidity and mortality. LHF impacts nearly 5.9 million adults and contributes to 1 out of every 9 deaths in the United States. Due to a lack of well-characterized animal models and the limitations of human subjects research, investigations into disease pathophysiology and progression have been limited and much of current understanding of the mechanisms of this disease remains speculative. We hypothesize the biomechanical and mechanobiological mechanisms are key to disease progression, especially at the pulmonary capillaries. In particular, we hypothesize the increased cyclic stretch and decreased wall shear stress drive the transition from isolated post-capillary pulmonary hypertension (aka pulmonary venous hypertension) to combined pre-/post-capillary pulmonary hypertension. To investigate these mechanical mechanisms, we apply multiscale computational and experimental approaches including in vitro studies, ex vivo studies, and in vivo studies in both large and small animal models of disease. We use a similar suite of methods to investigate the determinants of right ventricular failure, which is the common final pathway of mortality due to PH.

Host: Dr. Lori Setton, Washington University in St. Louis

NOTE:
Parking is available outside of Whitaker Hall in the East End Garage. Click here for the map. If taking the subway, the nearest metrolink stop is Skinker.