About this Event
6760 Forest Park Pkwy, St. Louis, MO 63105, USA
https://bme.wustl.edu/news-events/index.html #WashUBMEPresenting on "Biological tuning of the membrane phase transition facilitates plasma membrane organization and function".
Sarah Veatch, PhD, professor of biophysics and physics at the University of Michigan, will speak on Thursday, February 29, 2024 at 10:00 am CT in Whitaker 218.
Abstract: Isolated cell plasma membranes are biologically tuned to be in a single phase at growth temperature but close to a critical point of the membrane liquid-liquid phase transition. This talk will explore several consequences of this biological tuning through experiments in model and intact cell membranes. For example, near-critical membranes have a high compositional susceptibility, meaning that stable membrane domains can assemble in response to membrane proximal forces. This is demonstrated in live B cells through quantitative super-resolution nanoscopy measurements that detect the emergence of functional domains upon B cell receptor clustering. Near-critical tuning of the membrane phase transition can also enhance the stability of proteins condensed at membranes, and this is demonstrated through simulation and experiments in model and cellular systems.
Registration to attend virtually is required. Please register.