Sign Up

6760 Forest Park Pkwy, St. Louis, MO 63105, USA

#WashUBME

Presenting on “Tissue Engineered Disease Models to Study the Effect of Age on Disease Progression

Pinar Zorlutuna, PhD, Sheehan Family Collegiate Professor of Engineering and Acting Associate Dean for Diversity and Faculty Development at University of Notre Dame, will speak on Thursday, November 17, 2022 at 10:00 am CST in Whitaker 218.

Abstract: The fact that the most significant life-threatening diseases of our times such as Cardiovascular Diseases or Cancer remains the number one killer for over a century suggests that, despite the advancements in science and medicine over the years, there is a huge gap in translating these scientific findings to clinical setting. One of the major reasons for this gap is pre-clinical research’s heavy dependence on young animal models despite the fact that aging is the biggest risk factor for these diseases. For example, the average age for first heart attack is 65.3 years for males and 71.8 years for females, and most breast cancers develop in a postmenopausal, aged mammary gland tissue microenvironment at age of 62. Yet, due to the logistical limitations, current pre-clinical research predominately relies on experimental animals with a human-equivalent age of less than 35 years, which does not faithfully replicate the clinically prevailing aged tissue microenvironment. With increasing appreciation of the role of the tissue microenvironment in regulating disease progression and the response to therapeutics, there is an urgent need to develop, optimize and validate novel 3D culture systems that fully recapitulates the aged tissue microenvironment to reproducibly model natural disease progression. In this talk I will present our research in understanding biophysical and biochemical changes in the native tissue matrix with age and our efforts to create engineered tissue models that possess these variables to study myocardial infarction and breast cancer progression.

  • Justin Melendez
  • Justine Craig-Meyer
  • Nitin Shivannagari

3 people are interested in this event

6760 Forest Park Pkwy, St. Louis, MO 63105, USA

#WashUBME

Presenting on “Tissue Engineered Disease Models to Study the Effect of Age on Disease Progression

Pinar Zorlutuna, PhD, Sheehan Family Collegiate Professor of Engineering and Acting Associate Dean for Diversity and Faculty Development at University of Notre Dame, will speak on Thursday, November 17, 2022 at 10:00 am CST in Whitaker 218.

Abstract: The fact that the most significant life-threatening diseases of our times such as Cardiovascular Diseases or Cancer remains the number one killer for over a century suggests that, despite the advancements in science and medicine over the years, there is a huge gap in translating these scientific findings to clinical setting. One of the major reasons for this gap is pre-clinical research’s heavy dependence on young animal models despite the fact that aging is the biggest risk factor for these diseases. For example, the average age for first heart attack is 65.3 years for males and 71.8 years for females, and most breast cancers develop in a postmenopausal, aged mammary gland tissue microenvironment at age of 62. Yet, due to the logistical limitations, current pre-clinical research predominately relies on experimental animals with a human-equivalent age of less than 35 years, which does not faithfully replicate the clinically prevailing aged tissue microenvironment. With increasing appreciation of the role of the tissue microenvironment in regulating disease progression and the response to therapeutics, there is an urgent need to develop, optimize and validate novel 3D culture systems that fully recapitulates the aged tissue microenvironment to reproducibly model natural disease progression. In this talk I will present our research in understanding biophysical and biochemical changes in the native tissue matrix with age and our efforts to create engineered tissue models that possess these variables to study myocardial infarction and breast cancer progression.