About this Event
6760 Forest Park Pkwy, St. Louis, MO 63105, USA
https://bme.washu.edu/news-events/index.htmlPresenting on “Closed-Loop Brain Stimulation”.
Warren M. Grill, PhD, Edmund T. Pratt, Jr. School Distinguished Professor of Biomedical Engineering at Duke University, will speak on Thursday, February 6, 2025 at 10:00 am in Whitaker 218.
Abstract: Electrical stimulation of the nervous system is an effective therapy for a range of neurological diseases and disorders including chronic pain, Parkinson’s disease, urinary incontinence, epilepsy and deafness. These devices typically operate “open-loop”, and the parameters of stimulation (the dose) are invariant, even in the face of changes in the needs or activity of the patient. I will summarize our work to develop, implement, and evaluate closed-loop deep brain stimulation (DBS; a brain pacemaker) for the treatment of Parkinson’s disease. In closed-loop DBS, the parameters of stimulation is adjusted automatically in response to dynamic changes in brain signals. I will describe our efforts to characterize how brain signals very with the symptoms of PD, our initial evaluations of closed-loop DBS in the clinic, and our ongoing efforts to port use and evaluations to the home environment. Finally, I will highlight ongoing work to identify and exploit other potential feedback signals that can enable more informed adjustment of stimulation parameters. Collectively, this results highlights the potential of neural stimulation therapies responsive in real time to the needs of patients.
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