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McKelvey School of Engineering

Bioengineering Approaches to Modulate Stem Cells for Tissue Regeneration

Monday, September 20 | 1:30 PM - 2:30 PM

Stephen F. & Camilla T. Brauer Hall, 12
6548 Forest Park Pkwy, St. Louis, MO 63112, USA

Stem cells hold great therapeutic potential but, to date, have had limited applications in the clinical setting. Although transplantation of stem cells for regeneration of injured/diseased tissues has been extensively studied, several major barriers still remain, including low cell survival rate, poor control of differentiation, slow maturation, and low integration of grafted cells with the host tissue. I will discuss several bioengineering strategies to address these issues, such as improving stem cell survival through hydrogel-mediated formation of neovascular networks at brain lesion sites after traumatic or ischemic injuries, and expediting stem cell maturation through nanoparticle-mediated transcription activation. I will also discuss biomaterials approaches to manipulate endogenous cells for injured/diseased tissue regeneration.

Please note that for all in-person events, attendees must adhere to Washington University’s public health requirements, including the latest events and meetings protocol. Guests will be required to show a successful self-screening result and wear a mask at all times. 

Event Type

Lectures & Presentations, Seminar/Colloquia

Schools

Arts & Sciences, McKelvey School of Engineering, School of Medicine

Topic

Science & Technology, Medicine & Health

Website

https://imse.wustl.edu/

Department
Institute of Materials Science & Engineering
Hashtag

#IMSEseminar

Event Contact

Beth Gartin bgartin@wustl.edu

Speaker Information

Dr. Xiaowei Li received his PhD in Bioengineering from Clemson University in 2012. After his graduation, Dr. Li worked in the Translational Tissue Engineering Center at the Johns Hopkins School of Medicine as a postdoctoral fellow (2012-2015) and assistant research scientist (2015-2018). He was awarded the American Heart Association (AHA) Predoctoral Fellowship, Maryland Stem Cell Research Fund Postdoctoral Fellowship, and AHA Career Development Award. Dr. Li started his independent career at the University of Nebraska Medical Center in 2018, and joined the Department of Surgery at the Washington University School of Medicine in June 2021. Dr. Li’s laboratory focuses on developing biomaterials approaches to induce a permissive microenvironment to improve efficiency of stem cell therapies for regeneration of injured/diseased tissues, and also applying biomaterial platforms to influence endogenous cell fates to promote functional tissue regeneration.

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